Cortisol can weaken the activity of the immune system. Cortisol
prevents proliferation of T-cells by rendering the interleukin-2
producer T-cells unresponsive to interleukin-1 , and unable to
produce the T-cell growth factor.Cortisol also has a
negative-feedback effect on interleukin-1.IL-1 must be especially
useful in combating some diseases; however, endotoxic bacteria have
gained an advantage by forcing the hypothalamus to increase cortisol
levels (forcing the secretion of CRH hormone, thus antagonizing IL-1).
The suppressor cells are not affected by glucosteroid response-modifying
factor (GRMF), so the effective setpoint for the immune cells may
be even higher than the setpoint for physiological processes (reflecting
leukocyte redistribution to lymph nodes, bone marrow, and skin). Rapid
administration of corticosterone (the endogenous Type I and Type II
receptor agonist) orRU28362 (a specific Type II receptor agonist) to
adrenalectomized animals induced changes in leukocytedistribution.
Natural killer cells are not affected by cortisol
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